Drug interactions
Dexfenfluramine + Eletriptan
Severity: Moderate
Dexfenfluramine and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine releases serotonin and blocks its reuptake, so combining it with a triptan could contribute to serotonin syndrome. The drug has been withdrawn from most markets, so the interaction is mainly of historical interest.
What this interaction means in plain words
Dexfenfluramine and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from serotonin release and 5-HT1B/1D agonism.
What to do
Avoid the combination if dexfenfluramine is encountered. Otherwise monitor for agitation, tremor, hyperthermia and autonomic instability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Dexfenfluramine with Eletriptan?
MediHelp rates the interaction as moderate. Dexfenfluramine and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexfenfluramine releases serotonin and blocks its reuptake, so combining it with a triptan could contribute to serotonin syndrome. The drug has been withdrawn from most markets, so the interaction is mainly of historical interest.
How serious is the interaction between Dexfenfluramine and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if dexfenfluramine is encountered. Otherwise monitor for agitation, tremor, hyperthermia and autonomic instability.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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