Drug interactions
Dexfenfluramine + Ergotamine
Severity: Major
Dexfenfluramine and Ergotamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine increases serotonergic activity, and with ergotamine may add vasoconstrictive and serotonergic effects. This could cause hypertension, vasospasm or serotonin toxicity; dexfenfluramine is also withdrawn in most markets.
What this interaction means in plain words
Dexfenfluramine and Ergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic and vasoconstrictive effects.
What to do
Avoid combining; monitor blood pressure and for serotonin toxicity signs if exposure occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Dexfenfluramine with Ergotamine?
MediHelp rates the interaction as major. Dexfenfluramine and Ergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dexfenfluramine increases serotonergic activity, and with ergotamine may add vasoconstrictive and serotonergic effects. This could cause hypertension, vasospasm or serotonin toxicity; dexfenfluramine is also withdrawn in most markets.
How serious is the interaction between Dexfenfluramine and Ergotamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; monitor blood pressure and for serotonin toxicity signs if exposure occurs.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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