Drug interactions
Dexfenfluramine + Ranolazine
Severity: Minor
Dexfenfluramine and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine weakly inhibits CYP2D6 and could slightly raise levels of CYP2D6 substrates. Dexfenfluramine is a withdrawn product, and its metabolism involves several pathways, so the practical effect is likely minimal.
What this interaction means in plain words
Dexfenfluramine and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ranolazine weakly inhibits CYP2D6, possibly reducing dexfenfluramine metabolism.
What to do
No specific action is needed beyond awareness. Monitor for increased serotonergic adverse effects if the combination is ever used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexfenfluramine and Ranolazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Dexfenfluramine with Ranolazine?
MediHelp rates the interaction as minor. Dexfenfluramine and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine weakly inhibits CYP2D6 and could slightly raise levels of CYP2D6 substrates. Dexfenfluramine is a withdrawn product, and its metabolism involves several pathways, so the practical effect is likely minimal.
How serious is the interaction between Dexfenfluramine and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond awareness. Monitor for increased serotonergic adverse effects if the combination is ever used.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
