Drug interactions
Dexfenfluramine + Rizatriptan
Severity: Moderate
Dexfenfluramine and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine releases serotonin and blocks its reuptake. Combined with a triptan, serotonin syndrome is a theoretical risk. Dexfenfluramine has been withdrawn from most markets, so exposure is rare.
What this interaction means in plain words
Dexfenfluramine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity through serotonin release and reuptake inhibition plus 5-HT1B/1D agonism.
What to do
Monitor for serotonin syndrome features such as clonus, agitation, hyperthermia and diarrhea. Consider an alternative migraine therapy if the combination is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Dexfenfluramine with Rizatriptan?
MediHelp rates the interaction as moderate. Dexfenfluramine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexfenfluramine releases serotonin and blocks its reuptake. Combined with a triptan, serotonin syndrome is a theoretical risk. Dexfenfluramine has been withdrawn from most markets, so exposure is rare.
How serious is the interaction between Dexfenfluramine and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome features such as clonus, agitation, hyperthermia and diarrhea. Consider an alternative migraine therapy if the combination is needed.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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