Drug interactions
Dexlansoprazole + Lenacapavir
Severity: Minor
Dexlansoprazole and Lenacapavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor and may increase dexlansoprazole exposure. Because CYP3A4 is a secondary route and PPIs have a wide margin of safety, the clinical effect is expected to be small.
What this interaction means in plain words
Dexlansoprazole and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexlansoprazole belongs to Gastrointestinal Tract; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4, reducing a secondary pathway of dexlansoprazole clearance.
What to do
No dose adjustment is required. Monitor for PPI adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Dexlansoprazole with Lenacapavir?
MediHelp rates the interaction as minor. Dexlansoprazole and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir is a moderate CYP3A4 inhibitor and may increase dexlansoprazole exposure. Because CYP3A4 is a secondary route and PPIs have a wide margin of safety, the clinical effect is expected to be small.
How serious is the interaction between Dexlansoprazole and Lenacapavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor for PPI adverse effects.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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