Drug interactions
Dexlansoprazole + Mitotane
Severity: Moderate
Dexlansoprazole and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and may lower dexlansoprazole exposure, which could reduce acid suppression. The effect may persist for weeks after mitotane is stopped because of its long half-life.
What this interaction means in plain words
Dexlansoprazole and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexlansoprazole belongs to Gastrointestinal Tract; Mitotane belongs to Oncology.
Why it happens
Mitotane induces CYP3A4, increasing the metabolic clearance of dexlansoprazole.
What to do
Monitor for loss of acid control and increase the PPI dose or switch to an alternative if symptoms recur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Dexlansoprazole with Mitotane?
MediHelp rates the interaction as moderate. Dexlansoprazole and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and may lower dexlansoprazole exposure, which could reduce acid suppression. The effect may persist for weeks after mitotane is stopped because of its long half-life.
How serious is the interaction between Dexlansoprazole and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of acid control and increase the PPI dose or switch to an alternative if symptoms recur.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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