Drug interactions
Dexlansoprazole + Ritonavir
Severity: Minor
Dexlansoprazole and Ritonavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits CYP3A4 and may raise dexlansoprazole concentrations. The PPI has a wide safety margin, so the increase is usually of limited clinical consequence.
What this interaction means in plain words
Dexlansoprazole and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexlansoprazole belongs to Gastrointestinal Tract; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits CYP3A4, reducing the oxidative metabolism of dexlansoprazole.
What to do
No routine adjustment is needed; watch for PPI adverse effects such as headache or diarrhea during prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Dexlansoprazole with Ritonavir?
MediHelp rates the interaction as minor. Dexlansoprazole and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ritonavir inhibits CYP3A4 and may raise dexlansoprazole concentrations. The PPI has a wide safety margin, so the increase is usually of limited clinical consequence.
How serious is the interaction between Dexlansoprazole and Ritonavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for PPI adverse effects such as headache or diarrhea during prolonged use.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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