Drug interactions
Dexlansoprazole + Sparsentan
Severity: Moderate
Dexlansoprazole and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid suppression may reduce sparsentan absorption and exposure. This could weaken its proteinuria-lowering effect in IgA nephropathy.
What this interaction means in plain words
Dexlansoprazole and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexlansoprazole belongs to Gastrointestinal Tract; Sparsentan belongs to Genitourinary.
Why it happens
Increased gastric pH may reduce sparsentan solubility and absorption.
What to do
Monitor proteinuria and blood pressure response. Consider avoiding PPIs or switching to alternative acid-control if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexlansoprazole and Sparsentan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Dexlansoprazole with Sparsentan?
MediHelp rates the interaction as moderate. Dexlansoprazole and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Acid suppression may reduce sparsentan absorption and exposure. This could weaken its proteinuria-lowering effect in IgA nephropathy.
How serious is the interaction between Dexlansoprazole and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor proteinuria and blood pressure response. Consider avoiding PPIs or switching to alternative acid-control if response is inadequate.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
