Drug interactions
Dexmedetomidine + Dosulepin
Severity: Moderate
Dexmedetomidine and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant and its effects add to those of dexmedetomidine. Excess sedation, hypotension and bradycardia may occur, and tricyclic anticholinergic and cardiac effects add to the burden.
What this interaction means in plain words
Dexmedetomidine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmedetomidine belongs to Central Nervous System; Dosulepin belongs to Central Nervous System.
Why it happens
Additive CNS and cardiovascular depression from alpha-2 agonism and tricyclic antihistaminic and alpha-blocking effects.
What to do
Monitor sedation, blood pressure and heart rate, and reduce the dexmedetomidine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexmedetomidine
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dexmedetomidine with Dosulepin?
MediHelp rates the interaction as moderate. Dexmedetomidine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant and its effects add to those of dexmedetomidine. Excess sedation, hypotension and bradycardia may occur, and tricyclic anticholinergic and cardiac effects add to the burden.
How serious is the interaction between Dexmedetomidine and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and heart rate, and reduce the dexmedetomidine dose if needed.
What other medicines interact with Dexmedetomidine?
MediHelp also lists interactions of Dexmedetomidine with, for example, Buprenorphine long-acting, Calcium / magnesium / potassium / sodium oxybates, Dextromoramide. The full list is on the Dexmedetomidine page.
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