Drug interactions
Dexmedetomidine + Imipramine
Severity: Moderate
Dexmedetomidine and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmedetomidine is a sedative alpha-2 agonist, and imipramine adds CNS depression while also causing orthostatic hypotension. The combination can deepen sedation and increase hypotension or bradycardia. Tricyclics may also blunt alpha-2 agonist effects in some situations.
What this interaction means in plain words
Dexmedetomidine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmedetomidine belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and hemodynamic effects.
What to do
Titrate dexmedetomidine to sedation level and monitor blood pressure, heart rate and ECG. Reduce the dose if excessive sedation or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Dexmedetomidine with Imipramine?
MediHelp rates the interaction as moderate. Dexmedetomidine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmedetomidine is a sedative alpha-2 agonist, and imipramine adds CNS depression while also causing orthostatic hypotension. The combination can deepen sedation and increase hypotension or bradycardia. Tricyclics may also blunt alpha-2 agonist effects in some situations.
How serious is the interaction between Dexmedetomidine and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate dexmedetomidine to sedation level and monitor blood pressure, heart rate and ECG. Reduce the dose if excessive sedation or hypotension occurs.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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