Drug interactions
Dextroamphetamine + Duloxetine
Severity: Moderate
Dextroamphetamine and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise monoamine activity, so serotonin toxicity and additive increases in blood pressure and heart rate are possible. Duloxetine inhibits CYP2D6 moderately and may raise amphetamine exposure.
What this interaction means in plain words
Dextroamphetamine and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Duloxetine belongs to Central Nervous System.
Why it happens
Additive serotonergic and noradrenergic effects, with duloxetine inhibition of CYP2D6-mediated amphetamine metabolism.
What to do
Monitor blood pressure, heart rate and for serotonin toxicity signs, particularly after starting or changing doses. Reduce the dose or stop one agent if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Duloxetine?
MediHelp rates the interaction as moderate. Dextroamphetamine and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs raise monoamine activity, so serotonin toxicity and additive increases in blood pressure and heart rate are possible. Duloxetine inhibits CYP2D6 moderately and may raise amphetamine exposure.
How serious is the interaction between Dextroamphetamine and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and for serotonin toxicity signs, particularly after starting or changing doses. Reduce the dose or stop one agent if symptoms occur.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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