Drug interactions
Dextroamphetamine + Eletriptan
Severity: Moderate
Dextroamphetamine and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase synaptic serotonin and norepinephrine, and triptans act on serotonin receptors, so the combination could theoretically contribute to serotonin syndrome. Both agents can also raise blood pressure. Documented cases are scarce.
What this interaction means in plain words
Dextroamphetamine and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Eletriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic and sympathomimetic/vasoconstrictive effects.
What to do
Monitor blood pressure and for signs of serotonin toxicity such as agitation, tremor, hyperreflexia and hyperthermia. Stop the triptan if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Eletriptan?
MediHelp rates the interaction as moderate. Dextroamphetamine and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines increase synaptic serotonin and norepinephrine, and triptans act on serotonin receptors, so the combination could theoretically contribute to serotonin syndrome. Both agents can also raise blood pressure. Documented cases are scarce.
How serious is the interaction between Dextroamphetamine and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for signs of serotonin toxicity such as agitation, tremor, hyperreflexia and hyperthermia. Stop the triptan if symptoms develop.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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