Drug interactions
Dextroamphetamine + Esomeprazole
Severity: Minor
Dextroamphetamine and Esomeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reduced gastric acidity may speed up absorption of some amphetamine formulations, especially modified-release products, producing earlier peak concentrations. Overall exposure is generally unchanged.
What this interaction means in plain words
Dextroamphetamine and Esomeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextroamphetamine belongs to Central Nervous System; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH alters the release of pH-dependent amphetamine formulations and the absorption rate.
What to do
No routine change is needed. Monitor heart rate, blood pressure and effect timing in patients on extended-release products.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Esomeprazole?
MediHelp rates the interaction as minor. Dextroamphetamine and Esomeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reduced gastric acidity may speed up absorption of some amphetamine formulations, especially modified-release products, producing earlier peak concentrations. Overall exposure is generally unchanged.
How serious is the interaction between Dextroamphetamine and Esomeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor heart rate, blood pressure and effect timing in patients on extended-release products.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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