Drug interactions
Dextroamphetamine + Gepirone
Severity: Moderate
Dextroamphetamine and Gepirone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase synaptic serotonin in addition to catecholamines, and gepirone is a serotonergic antidepressant. Combined use may increase the risk of serotonin syndrome, with agitation, tremor, hyperthermia and autonomic instability.
What this interaction means in plain words
Dextroamphetamine and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Gepirone belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from amphetamine-induced serotonin release and gepirone 5-HT1A agonism.
What to do
Monitor for signs of serotonin syndrome, especially after starting or increasing either drug. Stop the serotonergic agents and treat if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Gepirone?
MediHelp rates the interaction as moderate. Dextroamphetamine and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines increase synaptic serotonin in addition to catecholamines, and gepirone is a serotonergic antidepressant. Combined use may increase the risk of serotonin syndrome, with agitation, tremor, hyperthermia and autonomic instability.
How serious is the interaction between Dextroamphetamine and Gepirone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome, especially after starting or increasing either drug. Stop the serotonergic agents and treat if symptoms develop.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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