Drug interactions
Dextroamphetamine + Methamphetamine
Severity: Major
Dextroamphetamine and Methamphetamine: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are amphetamine-class stimulants, so combining them duplicates therapy and increases the risk of hypertension, tachycardia, arrhythmias, agitation and dependence. Total stimulant exposure becomes difficult to control.
What this interaction means in plain words
Dextroamphetamine and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dextroamphetamine belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Additive release of norepinephrine and dopamine from therapeutic duplication.
What to do
Avoid using the two together and use a single stimulant at the lowest effective dose, with monitoring of blood pressure and heart rate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Methamphetamine?
MediHelp rates the interaction as major. Dextroamphetamine and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are amphetamine-class stimulants, so combining them duplicates therapy and increases the risk of hypertension, tachycardia, arrhythmias, agitation and dependence. Total stimulant exposure becomes difficult to control.
How serious is the interaction between Dextroamphetamine and Methamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the two together and use a single stimulant at the lowest effective dose, with monitoring of blood pressure and heart rate.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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