Drug interactions
Dextroamphetamine + Mirtazapine
Severity: Moderate
Dextroamphetamine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase serotonin and norepinephrine release and may add to serotonergic effects of mirtazapine, with a small risk of serotonin syndrome. Stimulation from the amphetamine may also counteract mirtazapine's sedation.
What this interaction means in plain words
Dextroamphetamine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive serotonergic and noradrenergic activity via amphetamine monoamine release and mirtazapine receptor effects.
What to do
Monitor for agitation, tremor, hyperthermia, tachycardia and other signs of serotonin toxicity, especially when starting or increasing doses. Stop the agents and treat if serotonin syndrome develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Mirtazapine?
MediHelp rates the interaction as moderate. Dextroamphetamine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines increase serotonin and norepinephrine release and may add to serotonergic effects of mirtazapine, with a small risk of serotonin syndrome. Stimulation from the amphetamine may also counteract mirtazapine's sedation.
How serious is the interaction between Dextroamphetamine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, tachycardia and other signs of serotonin toxicity, especially when starting or increasing doses. Stop the agents and treat if serotonin syndrome develops.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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