Drug interactions
Dextroamphetamine + Modafinil
Severity: Moderate
Dextroamphetamine and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents promote wakefulness, so combining them may increase insomnia, anxiety, irritability and cardiovascular stimulation. Modafinil may also modestly alter amphetamine absorption timing.
What this interaction means in plain words
Dextroamphetamine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Additive CNS stimulation through dopaminergic and noradrenergic pathways.
What to do
Monitor blood pressure, heart rate, sleep and anxiety, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dextroamphetamine and Modafinil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Dextroamphetamine with Modafinil?
MediHelp rates the interaction as moderate. Dextroamphetamine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents promote wakefulness, so combining them may increase insomnia, anxiety, irritability and cardiovascular stimulation. Modafinil may also modestly alter amphetamine absorption timing.
How serious is the interaction between Dextroamphetamine and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, sleep and anxiety, and use the lowest effective doses.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
