Drug interactions
Dextroamphetamine + Oxycodone
Severity: Minor
Dextroamphetamine and Oxycodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stimulants may partly offset opioid-induced drowsiness, which can mask sedation without reducing respiratory depression. Both drugs have additive effects on blood pressure and heart rate in some patients. Clinical significance is generally modest.
What this interaction means in plain words
Dextroamphetamine and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextroamphetamine belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
Opposing CNS effects (stimulant versus opioid) with possible additive sympathomimetic and serotonergic effects; no firmly established pharmacokinetic interaction.
What to do
Do not rely on alertness as a marker of opioid safety; monitor respiratory rate and cardiovascular status when starting or adjusting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Oxycodone?
MediHelp rates the interaction as minor. Dextroamphetamine and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stimulants may partly offset opioid-induced drowsiness, which can mask sedation without reducing respiratory depression. Both drugs have additive effects on blood pressure and heart rate in some patients. Clinical significance is generally modest.
How serious is the interaction between Dextroamphetamine and Oxycodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on alertness as a marker of opioid safety; monitor respiratory rate and cardiovascular status when starting or adjusting either drug.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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