Drug interactions
Dextroamphetamine + Tedizolid
Severity: Moderate
Dextroamphetamine and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine releases monoamines, and MAO inhibition reduces their breakdown, which can lead to hypertensive reactions and serotonin toxicity. Tedizolid is only a weak MAO inhibitor, so the risk is lower than with classic MAO inhibitors but not negligible.
What this interaction means in plain words
Dextroamphetamine and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Monoamine release combined with weak reversible MAO inhibition may increase catecholamine and serotonin levels.
What to do
Monitor blood pressure, heart rate and mental status during co-administration. Consider an alternative antibiotic in patients with uncontrolled hypertension or cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Tedizolid?
MediHelp rates the interaction as moderate. Dextroamphetamine and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextroamphetamine releases monoamines, and MAO inhibition reduces their breakdown, which can lead to hypertensive reactions and serotonin toxicity. Tedizolid is only a weak MAO inhibitor, so the risk is lower than with classic MAO inhibitors but not negligible.
How serious is the interaction between Dextroamphetamine and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and mental status during co-administration. Consider an alternative antibiotic in patients with uncontrolled hypertension or cardiovascular disease.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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