Drug interactions
Dextroamphetamine + Tramadol
Severity: Moderate
Dextroamphetamine and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents increase serotonergic and noradrenergic activity, so serotonin syndrome is possible. Both also lower the seizure threshold, and stimulants may mask opioid sedation without lessening respiratory depression.
What this interaction means in plain words
Dextroamphetamine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
Additive monoaminergic effects (release and reuptake inhibition) and additive seizure threshold lowering.
What to do
Monitor for agitation, tremor, tachycardia, hyperthermia and seizures, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Tramadol?
MediHelp rates the interaction as moderate. Dextroamphetamine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents increase serotonergic and noradrenergic activity, so serotonin syndrome is possible. Both also lower the seizure threshold, and stimulants may mask opioid sedation without lessening respiratory depression.
How serious is the interaction between Dextroamphetamine and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, tachycardia, hyperthermia and seizures, and use the lowest effective doses.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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