Drug interactions
Dextroamphetamine + Trimipramine
Severity: Major
Dextroamphetamine and Trimipramine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclics can potentiate the cardiovascular effects of amphetamines, producing hypertension, tachycardia and arrhythmias. Tricyclics may also reduce the uptake of amphetamine into neurons and inhibit its metabolism, and seizure risk rises.
What this interaction means in plain words
Dextroamphetamine and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dextroamphetamine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Tricyclic blockade of noradrenaline reuptake and CYP2D6 inhibition potentiates amphetamine sympathomimetic effects, with additive serotonergic and seizure-lowering effects.
What to do
Avoid the combination if possible. If needed, use low doses and monitor blood pressure, heart rate, ECG and signs of serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Trimipramine?
MediHelp rates the interaction as major. Dextroamphetamine and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclics can potentiate the cardiovascular effects of amphetamines, producing hypertension, tachycardia and arrhythmias. Tricyclics may also reduce the uptake of amphetamine into neurons and inhibit its metabolism, and seizure risk rises.
How serious is the interaction between Dextroamphetamine and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If needed, use low doses and monitor blood pressure, heart rate, ECG and signs of serotonin toxicity.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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