Drug interactions
Dextroamphetamine transdermal + Mirtazapine
Severity: Moderate
Dextroamphetamine transdermal and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines release monoamines including serotonin, and combining them with serotonergic antidepressants can contribute to serotonin syndrome. Mirtazapine has a relatively low serotonergic liability, so the risk is modest but real.
What this interaction means in plain words
Dextroamphetamine transdermal and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic and noradrenergic effects from amphetamine monoamine release and mirtazapine receptor effects.
What to do
Monitor for agitation, tremor, hyperthermia, clonus and tachycardia, especially at initiation or dose increases. Stop the amphetamine if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Dextroamphetamine transdermal with Mirtazapine?
MediHelp rates the interaction as moderate. Dextroamphetamine transdermal and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines release monoamines including serotonin, and combining them with serotonergic antidepressants can contribute to serotonin syndrome. Mirtazapine has a relatively low serotonergic liability, so the risk is modest but real.
How serious is the interaction between Dextroamphetamine transdermal and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, clonus and tachycardia, especially at initiation or dose increases. Stop the amphetamine if serotonin syndrome is suspected.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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