Drug interactions
Dextroamphetamine transdermal + Rizatriptan
Severity: Moderate
Dextroamphetamine transdermal and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines release serotonin along with other monoamines, so with rizatriptan the chance of serotonin syndrome may increase. Amphetamine-related blood pressure rises may also add to triptan vasoconstriction.
What this interaction means in plain words
Dextroamphetamine transdermal and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from amphetamine monoamine release and triptan 5-HT1 agonism.
What to do
Monitor for serotonin syndrome, particularly at initiation or dose increases, and check blood pressure. Stop the serotonergic agents if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Dextroamphetamine transdermal with Rizatriptan?
MediHelp rates the interaction as moderate. Dextroamphetamine transdermal and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines release serotonin along with other monoamines, so with rizatriptan the chance of serotonin syndrome may increase. Amphetamine-related blood pressure rises may also add to triptan vasoconstriction.
How serious is the interaction between Dextroamphetamine transdermal and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome, particularly at initiation or dose increases, and check blood pressure. Stop the serotonergic agents if it occurs.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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