Drug interactions
Dextroamphetamine transdermal + Trazodone
Severity: Major
Dextroamphetamine transdermal and Trazodone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase synaptic serotonin as well as catecholamines, and trazodone is serotonergic. Together they can raise the risk of serotonin syndrome, with agitation, tremor, hyperthermia and autonomic instability.
What this interaction means in plain words
Dextroamphetamine transdermal and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic activity from amphetamine-induced monoamine release and trazodone serotonin reuptake inhibition and receptor effects.
What to do
Start with low doses and titrate slowly, monitoring for serotonin syndrome particularly at initiation and dose increases. Remove the patch and stop the serotonergic drug if symptoms develop.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Dextroamphetamine transdermal with Trazodone?
MediHelp rates the interaction as major. Dextroamphetamine transdermal and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amphetamines increase synaptic serotonin as well as catecholamines, and trazodone is serotonergic. Together they can raise the risk of serotonin syndrome, with agitation, tremor, hyperthermia and autonomic instability.
How serious is the interaction between Dextroamphetamine transdermal and Trazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate slowly, monitoring for serotonin syndrome particularly at initiation and dose increases. Remove the patch and stop the serotonergic drug if symptoms develop.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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