Drug interactions
Dextromethorphan + Maprotiline
Severity: Minor
Dextromethorphan and Maprotiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline mainly inhibits norepinephrine reuptake with little serotonergic activity, so the serotonin syndrome risk with dextromethorphan is likely low. Maprotiline is metabolized by CYP2D6, so competition may raise levels of either drug.
What this interaction means in plain words
Dextromethorphan and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextromethorphan belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic effect and competition for CYP2D6; not well established.
What to do
No routine change is needed at usual doses; be aware of signs of serotonin toxicity or increased maprotiline adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Dextromethorphan with Maprotiline?
MediHelp rates the interaction as minor. Dextromethorphan and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maprotiline mainly inhibits norepinephrine reuptake with little serotonergic activity, so the serotonin syndrome risk with dextromethorphan is likely low. Maprotiline is metabolized by CYP2D6, so competition may raise levels of either drug.
How serious is the interaction between Dextromethorphan and Maprotiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed at usual doses; be aware of signs of serotonin toxicity or increased maprotiline adverse effects.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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