Drug interactions
Dextromethorphan + Ziprasidone
Severity: Minor
Dextromethorphan and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone prolongs the QT interval, and dextromethorphan's serotonergic activity gives a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome. Clinical reports of harm are rare.
What this interaction means in plain words
Dextromethorphan and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextromethorphan belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic and dopaminergic effects; the mechanism is not firmly established.
What to do
No routine dose change is needed; counsel the patient to report fever, rigidity, tremor, confusion or palpitations promptly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Dextromethorphan with Ziprasidone?
MediHelp rates the interaction as minor. Dextromethorphan and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ziprasidone prolongs the QT interval, and dextromethorphan's serotonergic activity gives a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome. Clinical reports of harm are rare.
How serious is the interaction between Dextromethorphan and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; counsel the patient to report fever, rigidity, tremor, confusion or palpitations promptly.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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