Drug interactions
Dextromoramide + Melatonin
Severity: Moderate
Dextromoramide and Melatonin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromoramide is a potent opioid analgesic that causes sedation and respiratory depression, and melatonin may add to drowsiness. Combined use increases the risk of impaired alertness.
What this interaction means in plain words
Dextromoramide and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid agonism and melatonin-mediated sedation.
What to do
Use the lowest effective doses and monitor sedation and respiratory rate; counsel against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Dextromoramide with Melatonin?
MediHelp rates the interaction as moderate. Dextromoramide and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextromoramide is a potent opioid analgesic that causes sedation and respiratory depression, and melatonin may add to drowsiness. Combined use increases the risk of impaired alertness.
How serious is the interaction between Dextromoramide and Melatonin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate; counsel against driving.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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