Drug interactions
Dextromoramide + Methamphetamine
Severity: Moderate
Dextromoramide and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromoramide is a potent opioid analgesic that causes sedation and respiratory depression, while methamphetamine is a stimulant. The stimulant may mask opioid sedation and lead to misjudgment of impairment, with overdose risk when stimulant effect wears off.
What this interaction means in plain words
Dextromoramide and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS pharmacodynamic effects of opioid agonism and amphetamine-induced monoamine release.
What to do
Monitor sedation, respiratory rate and cardiovascular status. Do not use the stimulant to offset opioid sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextromoramide with Methamphetamine?
MediHelp rates the interaction as moderate. Dextromoramide and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextromoramide is a potent opioid analgesic that causes sedation and respiratory depression, while methamphetamine is a stimulant. The stimulant may mask opioid sedation and lead to misjudgment of impairment, with overdose risk when stimulant effect wears off.
How serious is the interaction between Dextromoramide and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory rate and cardiovascular status. Do not use the stimulant to offset opioid sedation.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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