Drug interactions
Dextromoramide + Modafinil
Severity: Moderate
Dextromoramide and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromoramide is a potent opioid causing sedation and respiratory depression, while modafinil promotes wakefulness. Modafinil does not reliably reverse opioid respiratory depression, and its alerting effect may mask sedation.
What this interaction means in plain words
Dextromoramide and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic effects on arousal; modafinil does not antagonise opioid respiratory depression.
What to do
Monitor sedation level and respiratory rate, and titrate the opioid by analgesic need. Do not use modafinil to counter opioid sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dextromoramide and Modafinil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Modafinil
Frequently asked questions
Can I take Dextromoramide with Modafinil?
MediHelp rates the interaction as moderate. Dextromoramide and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextromoramide is a potent opioid causing sedation and respiratory depression, while modafinil promotes wakefulness. Modafinil does not reliably reverse opioid respiratory depression, and its alerting effect may mask sedation.
How serious is the interaction between Dextromoramide and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory rate, and titrate the opioid by analgesic need. Do not use modafinil to counter opioid sedation.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
