Drug interactions
Dextromoramide + Sevoflurane
Severity: Moderate
Dextromoramide and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromoramide is a potent opioid that adds to sevoflurane-induced sedation, respiratory depression and hypotension. Anesthetic requirements are reduced.
What this interaction means in plain words
Dextromoramide and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression via mu-opioid receptor agonism and volatile anesthetic action.
What to do
Titrate both agents to effect and monitor ventilation, oxygenation and hemodynamics continuously. Reduce the sevoflurane concentration when opioids are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Dextromoramide with Sevoflurane?
MediHelp rates the interaction as moderate. Dextromoramide and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextromoramide is a potent opioid that adds to sevoflurane-induced sedation, respiratory depression and hypotension. Anesthetic requirements are reduced.
How serious is the interaction between Dextromoramide and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate both agents to effect and monitor ventilation, oxygenation and hemodynamics continuously. Reduce the sevoflurane concentration when opioids are used.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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