Drug interactions
Diamorphine + Melatonin
Severity: Moderate
Diamorphine and Melatonin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diamorphine (heroin) is a potent opioid causing sedation and respiratory depression, and melatonin can add to drowsiness. The added effect of melatonin is probably small but not negligible.
What this interaction means in plain words
Diamorphine and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid agonism and melatonin-mediated sedation.
What to do
Monitor sedation level and respiratory rate, especially after dose changes, and avoid unnecessary additional sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Diamorphine with Melatonin?
MediHelp rates the interaction as moderate. Diamorphine and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diamorphine (heroin) is a potent opioid causing sedation and respiratory depression, and melatonin can add to drowsiness. The added effect of melatonin is probably small but not negligible.
How serious is the interaction between Diamorphine and Melatonin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory rate, especially after dose changes, and avoid unnecessary additional sedatives.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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