Drug interactions
Diazepam + Difelikefalin
Severity: Moderate
Diazepam and Difelikefalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin, a peripheral kappa-opioid agonist, can cause somnolence and dizziness, which may add to diazepam sedation. The effect is generally mild.
What this interaction means in plain words
Diazepam and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS depressant effects via different receptor mechanisms.
What to do
Monitor for drowsiness and dizziness, especially in dialysis patients prone to falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Diazepam with Difelikefalin?
MediHelp rates the interaction as moderate. Diazepam and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin, a peripheral kappa-opioid agonist, can cause somnolence and dizziness, which may add to diazepam sedation. The effect is generally mild.
How serious is the interaction between Diazepam and Difelikefalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and dizziness, especially in dialysis patients prone to falls.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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