Drug interactions
Diazepam + Eslicarbazepine
Severity: Moderate
Diazepam and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine inhibits CYP2C19 and weakly induces CYP3A4, so it may change diazepam and desmethyldiazepam levels in opposing directions. Both drugs are also sedating and may cause additive dizziness and somnolence.
What this interaction means in plain words
Diazepam and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Eslicarbazepine inhibits CYP2C19 and induces CYP3A4, altering diazepam metabolism, with additive CNS depression.
What to do
Monitor sedation and seizure or anxiety control, and adjust the diazepam dose based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Diazepam with Eslicarbazepine?
MediHelp rates the interaction as moderate. Diazepam and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine inhibits CYP2C19 and weakly induces CYP3A4, so it may change diazepam and desmethyldiazepam levels in opposing directions. Both drugs are also sedating and may cause additive dizziness and somnolence.
How serious is the interaction between Diazepam and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and seizure or anxiety control, and adjust the diazepam dose based on response.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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