Drug interactions
Diazepam + Etomidate
Severity: Moderate
Diazepam and Etomidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazepam given with etomidate produces additive sedation and may deepen anesthesia, with possible hypotension and respiratory depression. In procedural settings, the induction dose requirement may be lower.
What this interaction means in plain words
Diazepam and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Etomidate belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor-mediated CNS depression from both agents.
What to do
Titrate etomidate to effect and reduce the dose when the patient has received diazepam. Monitor airway, ventilation and blood pressure continuously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Diazepam with Etomidate?
MediHelp rates the interaction as moderate. Diazepam and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazepam given with etomidate produces additive sedation and may deepen anesthesia, with possible hypotension and respiratory depression. In procedural settings, the induction dose requirement may be lower.
How serious is the interaction between Diazepam and Etomidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate etomidate to effect and reduce the dose when the patient has received diazepam. Monitor airway, ventilation and blood pressure continuously.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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