Drug interactions
Diazepam + Etravirine
Severity: Moderate
Diazepam and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer but also inhibits CYP2C19, the main enzyme for diazepam activation and clearance, so the net effect is uncertain. Labeling for etravirine advises that diazepam concentrations may rise, with greater sedation, and a lower diazepam dose may be needed.
What this interaction means in plain words
Diazepam and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Etravirine belongs to Anti Virals.
Why it happens
Etravirine inhibits CYP2C19 and induces CYP3A4, altering diazepam metabolism, with net inhibition predicted by labeling.
What to do
Monitor for increased sedation and consider a lower diazepam dose. Reassess if etravirine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Diazepam with Etravirine?
MediHelp rates the interaction as moderate. Diazepam and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer but also inhibits CYP2C19, the main enzyme for diazepam activation and clearance, so the net effect is uncertain. Labeling for etravirine advises that diazepam concentrations may rise, with greater sedation, and a lower diazepam dose may be needed.
How serious is the interaction between Diazepam and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and consider a lower diazepam dose. Reassess if etravirine is stopped.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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