Drug interactions
Diazepam + Flibanserin
Severity: Moderate
Diazepam and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin and diazepam both cause sedation, somnolence and impaired alertness, so the combination can produce additive CNS depression. Diazepam is also a weak CYP3A4 inhibitor, which could modestly raise flibanserin exposure and add to dizziness, syncope and sedation.
What this interaction means in plain words
Diazepam and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Flibanserin belongs to Genitourinary.
Why it happens
Additive CNS depression, plus possible minor CYP3A4 inhibition by diazepam raising flibanserin levels.
What to do
Counsel the patient about additive drowsiness and advise against driving or hazardous activities until the response is known. Consider a lower benzodiazepine dose or an alternative, and monitor for excessive sedation or hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Flibanserin?
MediHelp rates the interaction as moderate. Diazepam and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin and diazepam both cause sedation, somnolence and impaired alertness, so the combination can produce additive CNS depression. Diazepam is also a weak CYP3A4 inhibitor, which could modestly raise flibanserin exposure and add to dizziness, syncope and sedation.
How serious is the interaction between Diazepam and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about additive drowsiness and advise against driving or hazardous activities until the response is known. Consider a lower benzodiazepine dose or an alternative, and monitor for excessive sedation or hypotension.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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