Drug interactions
Diazepam + Itraconazole
Severity: Moderate
Diazepam and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole inhibits CYP3A4, one of the enzymes that metabolizes diazepam, which can increase diazepam concentrations. This may lead to deeper or longer sedation and psychomotor impairment.
What this interaction means in plain words
Diazepam and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Itraconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated diazepam metabolism by itraconazole.
What to do
Monitor for excessive sedation and consider reducing the diazepam dose during itraconazole therapy; adjust again when itraconazole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Diazepam with Itraconazole?
MediHelp rates the interaction as moderate. Diazepam and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole inhibits CYP3A4, one of the enzymes that metabolizes diazepam, which can increase diazepam concentrations. This may lead to deeper or longer sedation and psychomotor impairment.
How serious is the interaction between Diazepam and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider reducing the diazepam dose during itraconazole therapy; adjust again when itraconazole is stopped.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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