Drug interactions
Diazepam + Lasmiditan
Severity: Moderate
Diazepam and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness and somnolence, and combined use with diazepam may add to CNS depression and psychomotor impairment. Interaction studies with CNS depressants have not been done.
What this interaction means in plain words
Diazepam and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Counsel patients not to drive for at least 8 hours after lasmiditan and monitor for excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Diazepam with Lasmiditan?
MediHelp rates the interaction as moderate. Diazepam and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness and somnolence, and combined use with diazepam may add to CNS depression and psychomotor impairment. Interaction studies with CNS depressants have not been done.
How serious is the interaction between Diazepam and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients not to drive for at least 8 hours after lasmiditan and monitor for excessive sedation.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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