Drug interactions
Diazepam + Lonafarnib
Severity: Moderate
Diazepam and Lonafarnib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib inhibits CYP3A and may inhibit CYP2C19, both involved in diazepam clearance, so diazepam exposure may rise with increased sedation. Diazepam is a weak CYP3A inhibitor that could slightly raise lonafarnib levels.
What this interaction means in plain words
Diazepam and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Lonafarnib belongs to Miscellaneous.
Why it happens
Lonafarnib inhibits CYP3A4 and CYP2C19 metabolism of diazepam; diazepam may weakly inhibit CYP3A-mediated lonafarnib clearance.
What to do
Monitor for oversedation and reduce the diazepam dose if needed. Watch for lonafarnib adverse effects such as gastrointestinal toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Diazepam with Lonafarnib?
MediHelp rates the interaction as moderate. Diazepam and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib inhibits CYP3A and may inhibit CYP2C19, both involved in diazepam clearance, so diazepam exposure may rise with increased sedation. Diazepam is a weak CYP3A inhibitor that could slightly raise lonafarnib levels.
How serious is the interaction between Diazepam and Lonafarnib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and reduce the diazepam dose if needed. Watch for lonafarnib adverse effects such as gastrointestinal toxicity.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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