Drug interactions
Diazepam + Lurasidone
Severity: Moderate
Diazepam and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use may produce additive drowsiness, dizziness and psychomotor impairment. Orthostatic hypotension may also be worsened, which raises the risk of falls, especially in older patients.
What this interaction means in plain words
Diazepam and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects of a benzodiazepine and a sedating atypical antipsychotic.
What to do
Monitor for sedation and orthostatic symptoms, particularly at initiation or dose increases. Counsel patients on avoiding driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Diazepam with Lurasidone?
MediHelp rates the interaction as moderate. Diazepam and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use may produce additive drowsiness, dizziness and psychomotor impairment. Orthostatic hypotension may also be worsened, which raises the risk of falls, especially in older patients.
How serious is the interaction between Diazepam and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic symptoms, particularly at initiation or dose increases. Counsel patients on avoiding driving and alcohol.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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