Drug interactions
Diazepam + Omeprazole
Severity: Moderate
Diazepam and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole reduces diazepam clearance, prolonging its half-life and sometimes increasing sedation and psychomotor impairment. The effect is most notable in extensive CYP2C19 metabolizers and in older adults.
What this interaction means in plain words
Diazepam and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Omeprazole inhibits CYP2C19-mediated demethylation of diazepam.
What to do
Monitor for excess sedation and reduce the diazepam dose if needed. Consider pantoprazole or another PPI with less CYP2C19 inhibition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Omeprazole?
MediHelp rates the interaction as moderate. Diazepam and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omeprazole reduces diazepam clearance, prolonging its half-life and sometimes increasing sedation and psychomotor impairment. The effect is most notable in extensive CYP2C19 metabolizers and in older adults.
How serious is the interaction between Diazepam and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and reduce the diazepam dose if needed. Consider pantoprazole or another PPI with less CYP2C19 inhibition.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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