Drug interactions
Diazepam + Ribociclib
Severity: Moderate
Diazepam and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may increase diazepam concentrations, lengthening and intensifying its sedative effects. The effect is likely modest because diazepam also has other metabolic routes such as CYP2C19.
What this interaction means in plain words
Diazepam and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing the metabolism of diazepam.
What to do
Monitor for excessive sedation and respiratory depression, and reduce the diazepam dose if these occur. Use the lowest effective benzodiazepine dose during ribociclib treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Diazepam with Ribociclib?
MediHelp rates the interaction as moderate. Diazepam and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4 and may increase diazepam concentrations, lengthening and intensifying its sedative effects. The effect is likely modest because diazepam also has other metabolic routes such as CYP2C19.
How serious is the interaction between Diazepam and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, and reduce the diazepam dose if these occur. Use the lowest effective benzodiazepine dose during ribociclib treatment.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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