Drug interactions
Diazepam + Selinexor
Severity: Moderate
Diazepam and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and fatigue, and diazepam may add to these CNS effects. No specific pharmacokinetic interaction is established.
What this interaction means in plain words
Diazepam and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Selinexor belongs to Oncology.
Why it happens
Additive CNS adverse effects; no specific pharmacokinetic mechanism established.
What to do
Monitor for dizziness, confusion and falls, particularly in older patients. Reduce or stop diazepam if neurological toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Diazepam with Selinexor?
MediHelp rates the interaction as moderate. Diazepam and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and fatigue, and diazepam may add to these CNS effects. No specific pharmacokinetic interaction is established.
How serious is the interaction between Diazepam and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and falls, particularly in older patients. Reduce or stop diazepam if neurological toxicity develops.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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