Drug interactions
Diazepam + Tazemetostat
Severity: Minor
Diazepam and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak to moderate CYP3A4 inducer and may lower diazepam exposure. Diazepam, a weak CYP3A4 substrate, is not expected to affect tazemetostat meaningfully. The effect on diazepam is usually modest.
What this interaction means in plain words
Diazepam and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diazepam belongs to Musculoskeletal; Tazemetostat belongs to Miscellaneous.
Why it happens
CYP3A4 induction by tazemetostat increases diazepam metabolism.
What to do
Monitor diazepam efficacy and adjust dose if the response is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Tazemetostat
Frequently asked questions
Can I take Diazepam with Tazemetostat?
MediHelp rates the interaction as minor. Diazepam and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak to moderate CYP3A4 inducer and may lower diazepam exposure. Diazepam, a weak CYP3A4 substrate, is not expected to affect tazemetostat meaningfully. The effect on diazepam is usually modest.
How serious is the interaction between Diazepam and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diazepam efficacy and adjust dose if the response is reduced.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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