Drug interactions
Diazepam + Temazepam
Severity: Moderate
Diazepam and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two benzodiazepines taken together produce additive sedation, psychomotor impairment and respiratory depression, with a higher risk of falls and dependence. The combination offers little therapeutic advantage.
What this interaction means in plain words
Diazepam and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Temazepam belongs to Central Nervous System.
Why it happens
Additive positive allosteric modulation of GABA-A receptors.
What to do
Avoid routine concurrent use of two benzodiazepines; if unavoidable, use the lowest effective doses and monitor sedation, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Diazepam with Temazepam?
MediHelp rates the interaction as moderate. Diazepam and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two benzodiazepines taken together produce additive sedation, psychomotor impairment and respiratory depression, with a higher risk of falls and dependence. The combination offers little therapeutic advantage.
How serious is the interaction between Diazepam and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use of two benzodiazepines; if unavoidable, use the lowest effective doses and monitor sedation, especially in older adults.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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