Drug interactions
Diazepam + Tipranavir
Severity: Major
Diazepam and Tipranavir: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, boosted with ritonavir, strongly inhibits CYP3A4 and can increase diazepam exposure. This may lead to prolonged sedation and respiratory depression.
What this interaction means in plain words
Diazepam and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diazepam belongs to Musculoskeletal; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4 and CYP2C19 metabolism of diazepam.
What to do
Avoid or use a substantially reduced diazepam dose with close monitoring for oversedation. Lorazepam is a preferable alternative.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diazepam
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Diazepam with Tipranavir?
MediHelp rates the interaction as major. Diazepam and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir, boosted with ritonavir, strongly inhibits CYP3A4 and can increase diazepam exposure. This may lead to prolonged sedation and respiratory depression.
How serious is the interaction between Diazepam and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or use a substantially reduced diazepam dose with close monitoring for oversedation. Lorazepam is a preferable alternative.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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