Drug interactions
Diazepam intranasal + Duloxetine
Severity: Moderate
Diazepam intranasal and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazepam is a benzodiazepine that depresses the CNS, and duloxetine can cause somnolence and dizziness. Co-use may increase sedation and impair psychomotor performance. Respiratory depression is uncommon but possible at higher benzodiazepine doses.
What this interaction means in plain words
Diazepam intranasal and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Monitor for sedation and respiratory status, particularly after a dose. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Duloxetine?
MediHelp rates the interaction as moderate. Diazepam intranasal and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazepam is a benzodiazepine that depresses the CNS, and duloxetine can cause somnolence and dizziness. Co-use may increase sedation and impair psychomotor performance. Respiratory depression is uncommon but possible at higher benzodiazepine doses.
How serious is the interaction between Diazepam intranasal and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory status, particularly after a dose. Advise patients to avoid driving and alcohol.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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