Drug interactions
Diazepam intranasal + Esomeprazole
Severity: Moderate
Diazepam intranasal and Esomeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esomeprazole inhibits CYP2C19, which helps metabolize diazepam, so diazepam levels and sedation may increase. Risk is greater in CYP2C19 poor metabolizers.
What this interaction means in plain words
Diazepam intranasal and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2C19-mediated demethylation of diazepam reduces its clearance.
What to do
Monitor for excessive sedation and respiratory depression, and reduce the diazepam dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Frequently asked questions
Can I take Diazepam intranasal with Esomeprazole?
MediHelp rates the interaction as moderate. Diazepam intranasal and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esomeprazole inhibits CYP2C19, which helps metabolize diazepam, so diazepam levels and sedation may increase. Risk is greater in CYP2C19 poor metabolizers.
How serious is the interaction between Diazepam intranasal and Esomeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, and reduce the diazepam dose if needed.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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