Drug interactions
Diazepam intranasal + Fluconazole
Severity: Moderate
Diazepam intranasal and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP2C19 and CYP3A4, the main pathways for diazepam clearance, so diazepam and its active metabolite may accumulate. This may cause deeper sedation, psychomotor impairment and respiratory depression.
What this interaction means in plain words
Diazepam intranasal and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2C19 and CYP3A4 metabolism of diazepam by fluconazole.
What to do
Monitor for excess sedation and respiratory depression and consider reducing the diazepam dose or dosing frequency. Warn patients about driving and other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Fluconazole?
MediHelp rates the interaction as moderate. Diazepam intranasal and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP2C19 and CYP3A4, the main pathways for diazepam clearance, so diazepam and its active metabolite may accumulate. This may cause deeper sedation, psychomotor impairment and respiratory depression.
How serious is the interaction between Diazepam intranasal and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and respiratory depression and consider reducing the diazepam dose or dosing frequency. Warn patients about driving and other CNS depressants.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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