Drug interactions
Diazepam intranasal + Gemfibrozil
Severity: Moderate
Diazepam intranasal and Gemfibrozil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil may inhibit CYP2C19 and slow diazepam elimination. This can prolong or intensify sedation and respiratory depression.
What this interaction means in plain words
Diazepam intranasal and Gemfibrozil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2C19-mediated diazepam metabolism, as predicted from gemfibrozil's inhibitory effects.
What to do
Monitor for excess sedation and respiratory depression; consider reducing the diazepam dose or frequency of repeat doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Gemfibrozil?
MediHelp rates the interaction as moderate. Diazepam intranasal and Gemfibrozil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil may inhibit CYP2C19 and slow diazepam elimination. This can prolong or intensify sedation and respiratory depression.
How serious is the interaction between Diazepam intranasal and Gemfibrozil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and respiratory depression; consider reducing the diazepam dose or frequency of repeat doses.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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